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Literatur NatGesIs

Efficacy of Injection Immunotherapy with Ragweed and Birch Pollen in Elderly Patients



Dokumenttyp

Zeitschriftenartikel



Autor/en

Asero, R.



Jahr

2004



Zeitschrift/Schriftenreihe

International Archives of Allergy and Immunology



Heft

135



Seiten

332 - 335



Beschreibung

Background: The role of specific immunotherapy (SIT) in
elderly allergic patients is still debated.
Objective: The aim of this study was to assess whether SIT is associated with a better control of symptoms and a better quality of life also in older allergic patients.
Methods: The effect of injection SIT was assessed in 39 patients [age 154 years, median 59; 29 patients (74%) with asthma, otherwise healthy] monosensitized to birch (n = 20) and ragweed (n = 19). Thirty-three younger subjects [age !50 years, median 35; 26 patients (79%) with asthma, otherwise healthy] mono-sensitized to birch (n = 10) and ragweed (n = 23), and 37 subjects 154 years old (25 males/12 females; age 55-79 years, median 59 years) monosensitized to birch (n = 18) and ragweed (n = 19) who refused to undergo SIT were enrolled as positive and negative controls, respectively. All groups had a disease duration 10 years; the disease was inadequately controlled with standard drug therapies in all cases. SIT was carried out using the same extracts and was administered using a
perennial schedule both in patients and controls. Seasonal
therapies were the same in all groups and were not
changed after SIT was started. After 1-5 years of SIT,
patients and controls were asked to quantify symptom
reduction on a visual analogue scale: reductions 150%
were considered significant. Moreover, the use of cetirizine
and/or salbutamol as an adjunct to standard therapies
during the last pollen season was assessed as an objective measure of SIT outcome.
Results: 37/39 (95%) patients versus 32/33 (97%) controls submitted to SIT reported a symptom reduction 150% after 1-5 years of SIT (nonsignificant). The median clinical efficacy of SIT was 80% in both groups (nonsignificant). 27/37 controls not submitted to SIT did not report any change in symptom severity at the follow-up visits, whereas 10/37 reported a more severe disease (4 subjects reported the appearance of seasonal asthma) (p ! 0.001 vs. patients
submitted to SIT). Patients used less frequently cetirizine
(p ! 0.001) and/or salbutamol (p ! 0.05) than controls not
submitted to SIT.
Conclusion: Injection SIT can be considered an effective therapeutic option in otherwise healthy elderly patients with a short disease duration whose symptoms cannot be adequately controlled by drug therapies alone.



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